Clarke County is a county in Alabama located in the southwestern part of the state. The county seat is Grove Hill, and the county is divided into five districts.

The government of Clarke County, Alabama is composed of a five-member Board of County Commissioners, elected from single-member districts. The Board is responsible for setting the county's budget, levying taxes, and making policy decisions. The County Commission is the legislative body of the county government and has the authority to pass ordinances and resolutions.

The economy of Clarke County is largely supported by the timber and farming industries, as well as manufacturing and trade. The county also has a substantial tourism industry.

U.S. Route 84 and U.S. Route 43 serve as the primary highways in Clarke County. The Amtrak station in Grove Hill serves as the nearest train station. The Mobile Regional Airport is located approximately 75 miles away in Mobile, Alabama.

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